Determination of levels of current drugs in hospital and urban wastewater.
Identifieur interne : 000442 ( France/Analysis ); précédent : 000441; suivant : 000443Determination of levels of current drugs in hospital and urban wastewater.
Auteurs : Elodie Saussereau [France] ; Christian Lacroix ; Michel Guerbet ; Dominique Cellier ; Joël Spiroux ; Jean-Pierre GoulléSource :
- Bulletin of environmental contamination and toxicology [ 1432-0800 ] ; 2013.
English descriptors
- KwdEn :
- Adrenergic beta-Antagonists (analysis), Analgesics (analysis), Anesthetics (analysis), Anti-Anxiety Agents (analysis), Anticonvulsants (analysis), Antidepressive Agents (analysis), Cardiovascular Agents (analysis), Chromatography, High Pressure Liquid, Environmental Monitoring (methods), Histamine Antagonists (analysis), Hospitals, Pharmaceutical Preparations (analysis), Rivers (chemistry), Tandem Mass Spectrometry, Waste Water (chemistry), Water Pollutants, Chemical (analysis).
- MESH :
- chemical , analysis : Adrenergic beta-Antagonists, Analgesics, Anesthetics, Anti-Anxiety Agents, Anticonvulsants, Antidepressive Agents, Cardiovascular Agents, Histamine Antagonists, Pharmaceutical Preparations, Water Pollutants, Chemical.
- chemistry : Rivers, Waste Water.
- methods : Environmental Monitoring.
- Chromatography, High Pressure Liquid, Hospitals, Tandem Mass Spectrometry.
Abstract
A rapid, sensitive and highly specific HPLC-MS/MS method with direct on-line preparation was applied for the determination of 20 common pharmaceuticals in hospital and urban wastewater. Median drug concentrations were quite similar in the majority of samples, cerca 1 μg L⁻¹ ranging from 0.06 to 2.67 μg L⁻¹ in both water. Pharmaceutical hospital contribution, below 1 %, was negligible, as compared to the huge amount in the municipal plant flow. Due to only partial elimination in the plant, hundreds of kilograms of harmful waste per year are discharged in the River Seine. Therefore, to reduce potential human and environmental exposure, a topic of major concern, an efficient drug treatment procedure should be used at the municipal plant stage in order to reduce urban wastewater pollution. The HPLC-MS/MS method could be a very useful tool to optimize the pharmaceutical wastewater treatment process.
DOI: 10.1007/s00128-013-1030-7
PubMed: 23807682
Affiliations:
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pubmed:23807682Le document en format XML
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last="Lacroix">Christian Lacroix</name></author><author><name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name></author><author><name sortKey="Cellier, Dominique" sort="Cellier, Dominique" uniqKey="Cellier D" first="Dominique" last="Cellier">Dominique Cellier</name></author><author><name sortKey="Spiroux, Joel" sort="Spiroux, Joel" uniqKey="Spiroux J" first="Joël" last="Spiroux">Joël Spiroux</name></author><author><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23807682</idno><idno type="pmid">23807682</idno><idno type="doi">10.1007/s00128-013-1030-7</idno><idno type="wicri:Area/PubMed/Corpus">000159</idno><idno type="wicri:Area/PubMed/Curation">000159</idno><idno 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Toxicologie Cliniques, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name></author><author><name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name></author><author><name sortKey="Cellier, Dominique" sort="Cellier, Dominique" uniqKey="Cellier D" first="Dominique" last="Cellier">Dominique Cellier</name></author><author><name sortKey="Spiroux, Joel" sort="Spiroux, Joel" uniqKey="Spiroux J" first="Joël" last="Spiroux">Joël Spiroux</name></author><author><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name></author></analytic><series><title level="j">Bulletin of environmental contamination and toxicology</title><idno type="eISSN">1432-0800</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Antagonists (analysis)</term><term>Analgesics (analysis)</term><term>Anesthetics (analysis)</term><term>Anti-Anxiety Agents (analysis)</term><term>Anticonvulsants (analysis)</term><term>Antidepressive Agents (analysis)</term><term>Cardiovascular Agents (analysis)</term><term>Chromatography, High Pressure Liquid</term><term>Environmental Monitoring (methods)</term><term>Histamine Antagonists (analysis)</term><term>Hospitals</term><term>Pharmaceutical Preparations (analysis)</term><term>Rivers (chemistry)</term><term>Tandem Mass Spectrometry</term><term>Waste Water (chemistry)</term><term>Water Pollutants, Chemical (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Adrenergic beta-Antagonists</term><term>Analgesics</term><term>Anesthetics</term><term>Anti-Anxiety Agents</term><term>Anticonvulsants</term><term>Antidepressive Agents</term><term>Cardiovascular Agents</term><term>Histamine Antagonists</term><term>Pharmaceutical Preparations</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Rivers</term><term>Waste Water</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Environmental Monitoring</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Hospitals</term><term>Tandem Mass Spectrometry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A rapid, sensitive and highly specific HPLC-MS/MS method with direct on-line preparation was applied for the determination of 20 common pharmaceuticals in hospital and urban wastewater. Median drug concentrations were quite similar in the majority of samples, cerca 1 μg L⁻¹ ranging from 0.06 to 2.67 μg L⁻¹ in both water. Pharmaceutical hospital contribution, below 1 %, was negligible, as compared to the huge amount in the municipal plant flow. Due to only partial elimination in the plant, hundreds of kilograms of harmful waste per year are discharged in the River Seine. Therefore, to reduce potential human and environmental exposure, a topic of major concern, an efficient drug treatment procedure should be used at the municipal plant stage in order to reduce urban wastewater pollution. The HPLC-MS/MS method could be a very useful tool to optimize the pharmaceutical wastewater treatment process.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Cellier, Dominique" sort="Cellier, Dominique" uniqKey="Cellier D" first="Dominique" last="Cellier">Dominique Cellier</name><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name><name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><name sortKey="Spiroux, Joel" sort="Spiroux, Joel" uniqKey="Spiroux J" first="Joël" last="Spiroux">Joël Spiroux</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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